Publicaciones

αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model

Publicado en: Protein Cell Martinez-Redondo, P., Guillen-Guillen, I., Davidsohn, N. et al. αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a ...
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Instant CEMTRO Cell (ICC), implante de condrocitos autólogos de alta densidad

Publicado en: Revista Española de Artroscopia y Cirugía Articular (REACA) La medicina regenerativa es una nueva disciplina de la medicina, ...
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Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis

Publicado en: Nature Communications Abstract. DiGeorge syndrome critical region 8 (DGCR8) is a critical component of the canonical microprocessor complex ...
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High-Density Autologous Chondrocyte Implantation as Treatment for Ankle Osteochondral Defects

Publicado en: Cartilage Purpose. Two-year follow-up to assess efficacy and safety of high-density autologous chondrocyte implantation (HD-ACI) in patients with ...
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https://pubmed.ncbi.nlm.nih.gov/29322876/

Publicado en: CARTILAGE Abstract. In the process of cell division, the extremes of the eukaryotic chromosomes are progressively shortening, and this phenomenon ...
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In Vivo Target Gene Activation via CRISPR/Cas9- Mediated Trans-epigenetic Modulation

Publicado en: Cell Summary Current genome-editing systems generally rely on inducing DNA double-strand breaks (DSBs). This may limit their utility in ...
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Cartilage Defect Treatment Using High-Density Autologous Chondrocyte Implantation: Two-Year Follow-up

Publicado en: Cartilage Objective. The aim of this work was to study the short- and mid-term effectiveness and safety of ...
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Interspecies chimerism with mammalian pluripotent stem cells

Publicado en: Cell Interspecies blastocyst complementation enables organ-specific enrichment of xenogenic pluripotent stem cell (PSC) derivatives. Here, we establish a versatile blastocyst complementation platform ...
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In vivo genome editing via CRISPR-Cas9 mediated homology-independent targeted integration

Publicado en: Nature Targeted genome editing via engineered nucleases is an exciting area of biomedical research and holds potential for ...
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