Publicado en: Nature Communications
Abstract. In this work we describe the use of high-density autologous chondrocyte implantation
(HD-ACI) to treat 2 patients with chondral defects in the hip.
Case Presentation: Two male, 35- and 37-year-old, with chondral lesions and femoroacetabular
impingement (FAI) were included. Chondrocytes were isolated expanded in vitro and then implanted
at a density of 5 million cells per cm 2 onto a type I/III porcine collagen membrane. None
of the patients had surgery-derived complications. Pain disappeared in both cases at 6 months
after surgery and was maintained until follow-up end (36 months). International Hip Outcome
Tool (iHOT) score increased at 6 and 12 months and then leveled off until month 36.Three-year
arthro-MRI showed the cartilage defects had been filled with a material similar to the surrounding
Conclusion: HD-ACI is a safe and effective technique for focal cartilage lesion treatment in patients
affected by evolved FAI.
Torres-Eguia R, Lopez-Alcorocho JM, Rodriguez-Iñigo E, Guillen-Vicente I, Guillen-Vicente M, Diaz-Navarro ME, Aboli L, Fernández-Jaén TF, Guillen-Garcia P. The use of high-density autologous chondrocytes implant for the treatment of hip joint chondral defects. Journal of Cartilage & Joint preservation 2022