Publicado en: Nature Communications
Abstract. Bilateral knee chondral defects can be treated in one or two surgical acts.
Objectives: To study clinical outcome of patients with bilateral knee chondral defects treated with
High-Density Autologous Chondrocyte Implantation (HD-ACI) during the same surgery.
Methods: Study on eight patients (4 women and 4 men) with chondral defects in both knees
treated with HD-ACI during the same surgical act. Patients were evaluated 2, 6, 12 and 24 months
post-op for treatment safety and efficacy: visual analogic scale (VAS) for pain, International Knee
Documentation Committee (IKDC) for subjective patient’s perception of both knees and EuroQol
five-dimensional five-level questionnaire (EQ-5D-5 L) for quality of life. Integrity of neoformed
tissue at 12 and 24-month follow-up was assessed by the magnetic resonance observation of
cartilage repair tissue (MOCART) score.
Results: VAS decreased from baseline to 24 months from a median of 8 (6 – 9) to a median of 0 (0
– 5) ( P < .001). IKDC increased from a median value of 39.0 (17.2 – 48.3) in the basal visit to a
median of 83.7 (24.0 – 98.0) in the 24-month visit ( P < .001). EQ-5D-5 L decreased at 2 months
post-op and increased throughout the follow-up visits thereafter, needing 24 months after surgery
to reach a value higher than the basal one. Median MOCART at 12 months was 80.3 (58.0 – 89.7)
and 81.3 (54.0 – 89.9) at 24 months.
Guillén-Vicente I, López-Alcorocho JM, Rodríguez-Iñigo E, Guillén-Vicente M, Fernández-Jaén TF, Cortés JM, Abelow S, Guillén-García P. High-Density Autologous Chondrocyte Implantation (HD-ACI) in patients with bilateral knee chondral defects. Journal of Cartilage & Joint Preservation TM 1 (2021) 100013