Publicado en: Nature Communications
Abstract. To study clinical outcome of patients with bilateral ankle chondral defects treated with High-Density
Autologous Chondrocyte Implantation (HD-ACI) in the same surgical act.
Cases presentation: Two men (27 and 48 years-old) with chondral defects in both ankles evidenced by MRI. Chondral
lesions were treated with HD-ACI in the same surgical act and anesthesia, consecutively. Patients were evaluated
2, 6 and 12 months after surgery to check for treatment safety and efficacy. Pain, evaluated by the Visual
Analogic Scale (VAS), decreased from very high values (8.5 – 9) to normal or almost scores one year after surgery (0-1). Ankle functionality measured by the American Orthopedic Foot & Ankle Society score (AOFAS) and quality of life evaluated by the EuroQol five-dimensional five-level questiionnaire (EQ-5D-5L) behaved similarly to pain. Thus, both parameters increased and/or slightly decreased at 2 months (AOFAS socre: 90 and 89; EQ-5D-5L score: 0.89 and 0.91). MRI from both ankles revelaed that chondral defects were filled with a material of similar aspect to the surrounding cartilage.
Guillen-Vicente I, Lopez-Alcorocho JM, Rodríguez-Iñigo E, Navarro R, Guillén-Vicente M, Fernández-Jaen T, Guillén-García P. High density autologous chondrocyte implantation for the treatment of bilateral ankle cartilage defects: Report of two cases. Foot and ankle surgery: Techniques reports and cases 2 (2022) 100218